Rat Fructose-1, 6-bisphosphatase 1, FBP1 ELI

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis.

Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells.

Appears to modulate glycerol gluconeogenesis in liver.

Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.