Rat GATA binding protein 4,GATA4 ELI

Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (By similarity).

In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (By similarity).

Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity).

Promotes cardiac myocyte enlargement (By similarity).

Required during testicular development (By similarity).

Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (PubMed:15329343).

Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343).

May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (By similarity).

{ECO:0000250|UniProtKB:P43694, ECO:0000250|UniProtKB:Q08369, ECO:0000269|PubMed:15329343}.