Rat Glucocorticoid Receptor, GR ELI

Receptor for glucocorticoids (GC).

Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors.

Affects inflammatory responses, cellular proliferation and differentiation in target tissues.

Involved in chromatin remodeling (PubMed: 12917342).

Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity).

Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity).

[Isoform A]: Has transcriptional activation and repression activity.

Mediates glucocorticoid-induced apoptosis.

Promotes accurate chromosome segregation during mitosis.

May act as a tumor suppressor.

May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression.