Rat Glucose Transporter 4, GLUT4 ELI

Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation (PubMed: 2649253, PubMed: 2645527, PubMed: 2211693).

Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells (PubMed: 2649253, PubMed: 2645527, PubMed: 2211693).

Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell (PubMed: 2649253, PubMed: 2645527, PubMed: 2211693).