Rat Glutamate receptor 1,Gria1 ELI

Ionotropic glutamate receptor.

L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse.

The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.

In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

{ECO:0000269|PubMed:16793768, ECO:0000269|PubMed:19265014}.