Rat Hypoxia-inducible Factor 3-alpha, HIF3A ELI

Acts as a transcriptional regulator in adaptive response to low oxygen tension.

Attenuates the ability of transcription factor HIF1A, EPAS1 and the HIF1A-ARNT complex to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation.

Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea.

Plays a role in the development of the cardiorespiratory system.

May also be involved in apoptosis.

May act as a tumor suppressor.