Rat Macrophage Inflammatory Protein 1Α, MIP1A ELI

Monokine with inflammatory and chemokinetic properties.

Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes.

Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx.

This protein binds heparin.