Rat Matrix Metalloproteinase-16, MMP16 ELI

Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin.

Activates progelatinase A.

Involved in the matrix remodeling of blood vessels.

The short isoform efficiently converts progelatinase A to the intermediate form but not to the mature one.

It has no effect on type I, II, IV and V collagen.

However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.