Rat matrix metalloproteinase 24,MMP-24 ELI
3,140.00 ₪
Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence.
Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia.
Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence.
May play a role in axonal growth.
Able to activate progelatinase A.
May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans.
Cleaves partially fibronectin, but not collagen type I, nor laminin.
{ECO:0000269|PubMed:16495457}.
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