Rat Mothers Against Decapentaplegic Homolog 1, SMAD1 ELI

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase.

SMAD1 is a receptor-regulated SMAD (R-SMAD).

Has been shown to be also activated by TGF-beta (transforming growth factor) type I receptor kinase in rat intestinal epithelial cells (IEC 4-1).

SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.

May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity).