Rat Multidrug Resistance-associated Protein 1, ABCC1 ELI

Mediates export of organic anions and drugs from the cytoplasm.

Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics.

Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export.

Hydrolyzes ATP with low efficiency (PubMed: 15129170).

Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed: 17050692).

Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity).