Rat Myeloid differentiation primary response protein MyD88,MYD88 ELI

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.

Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Increases IL-8 transcription.

Involved in IL-18-mediated signaling pathway.

Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes.

Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity).

MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).

{ECO:0000250|UniProtKB:P22366, ECO:0000250|UniProtKB:Q99836}.