Rat Neprilysin, NEP ELI

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed: 2966343) (By similarity).

Biologically important in the destruction of opioid Peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed: 2966343) (By similarity).

Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed: 2966343) (By similarity).

Involved in the degradation of the atrial natriuretic factor (ANF) (PubMed: 2966343).

Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (By similarity).