Rat Nesfatin 1, NES-1 ELI

Calcium-binding protein which may have a role in calcium homeostasis (By similarity).

Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (PubMed: 21653697).

[Nesfatin-1]: Anorexigenic Peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner.

May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance.