Rat Neuromedin U,NMU ELI

[Neuromedin-U-23]: Ligand for receptors NMUR1 and NMUR2 (PubMed:28874765).

Receptor-binding is very tight if not irreversible and triggers an increase in the cytosolic Ca(2+) concentration (PubMed:28874765).

Stimulates muscle contractions of specific regions of the gastrointestinal tract.

In rat, NMU stimulates contractions of stomach circular muscle.

{ECO:0000269|PubMed:28874765}.; [Neuromedin precursor-related peptide 33]: Does not function as a ligand for either NMUR1 or NMUR2 (PubMed:28874765).

Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36 (PubMed:28874765).

{ECO:0000269|PubMed:28874765}.; [Neuromedin precursor-related peptide 36]: Does not function as a ligand for either NMUR1 or NMUR2.

Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system.

{ECO:0000269|PubMed:28874765}.