Rat Peripheral Plasma Membrane Protein Cask, CASK ELI

Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion Channel trafficking.

Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1.

Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans.

May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.

Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity).