Rat Prostatic Acid Phosphatase, PAP ELI

[Isoform 1]: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins.

Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.

[Isoform 2]: In addition to its tyrosine phosphatase activity, also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons.

Generates adenosine from AMP.

This extracellular adenosine leads to a decrease in chronic pain by activating A1R in nociceptive neurons.