Rat Rho Guanine Nucleotide Exchange Factor 7,ARHGEF7 ELI

Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling.

Functions in cell migration, attachment and cell spreading.

Promotes targeting of RAC1 to focal adhesions.

May function as a positive regulator of apoptosis.

Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity).

{ECO:0000250}.