Rat Runt-related Transcription Factor 1, RUNX1 ELI
3,140.00 ₪
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters.
The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis.
Isoform AML-1L interferes with the transactivation activity of RUNX1.
Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter.
Inhibits KAT6B-dependent transcriptional activation.
Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3.
Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (By similarity). Positively regulates the expression of RORC in T-helper 17 cells (By similarity).
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