Rat Runt-related Transcription Factor 2, RUNX2 ELI

Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis.

Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification.

CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters.

Inhibits KAT6B-dependent transcriptional activation.

In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).