Rat Ryanodine receptor 1,RyR1 ELI

Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11316255).

Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (By similarity).

Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain.

Required for normal embryonic development of muscle fibers and skeletal muscle.

Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).

{ECO:0000250|UniProtKB:E9PZQ0, ECO:0000250|UniProtKB:P11716, ECO:0000305|PubMed:11316255}.