Rat Ryanodine Receptor 2, RYR2 ELI

Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction.

Aberrant channel activation can lead to cardiac arrhythmia.

In cardiac myocytes, calcium release is triggered by increased Ca2+ levels due to activation of the L-type calcium channel CACNA1C.

The calcium channel activity is modulated by formation of heterotetramers with RYR3.

Required for cellular calcium ion homeostasis.

Required for embryonic heart development (By similarity).