Rat Serine, Threonine-protein Kinase Tao2, TAOK2 ELI

Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade.

Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins.

Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases.

In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases.

May affect microtubule organization and stability.

May play a role in the osmotic stress-MAPK8 pathway.

Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation.

Isoform 2, but not isoform 1, is required for PCDH8 endocytosis.

Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2.

This process leads to PCDH8 endocytosis and CDH2 cointernalization.

Both isoforms are involved in MAPK14/p38 MAPK activation.