Rat SH2 domain-containing inositol 5'-phosphatase 1,SHIP1 ELI

Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:8910587).

Also able to hydrolyze the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (By similarity).

Acts as a negative regulator of B-cell antigen receptor signaling.

Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems.

Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells.

Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance.

Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity.

Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis.

Modulates FCGR3/CD16-mediated cytotoxicity in NK cells.

Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression (By similarity).

{ECO:0000250|UniProtKB:Q92835, ECO:0000269|PubMed:8910587}.