Rat soluble Interleukin-1 receptor type 2,sIL-1R2 ELI

Non-signaling receptor for IL1A, IL1B and IL1RN.

Reduces IL1B activities.

Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1.

Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B.

IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN.

The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity).

{ECO:0000250}.