Rat Solute Carrier Family 22 Member 2, SLC22A2 ELI

Mediates tubular uptake of organic compounds from circulation.

Mediates the influx of agmatine, serotonin, choline, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP and amiloride (By similarity). Mediates the influx of adrenaline, noradrenaline (norepinephrine), dopamine, cimetidine, famotidine, metformin, N-1-methylnicotinamide (NMN), 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), oxaliplatin and cisplatin.

Cisplatin may develop a nephrotoxic action.

Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX.

This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.