Rat Spexin,C12orf39 ELI

Plays a role as a central modulator of cardiovascular and renal function and nociception.

Plays also a role in energy metabolism and storage.

Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (PubMed:20045034, PubMed:22038051).

{ECO:0000269|PubMed:20045034, ECO:0000269|PubMed:22038051}.; [Spexin-1]: Acts as a ligand for galanin receptors GALR2 and GALR3 (By similarity).

Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis.

Intraventricular administration of the peptide induces antinociceptive activity.

Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight.

Inhibits long chain fatty acid uptake into adipocytes.

Also induces contraction of muscarinic-like stomach smooth muscles (PubMed:24550067).

{ECO:0000250, ECO:0000269|PubMed:24550067}.; [Spexin-2]: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate.

Intraventricular administration of the peptide induces antinociceptive activity (PubMed:22038051).

{ECO:0000269|PubMed:22038051}.