Rat Steroid Receptor RNA Activator 1,SRA1 ELI

Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors.

Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2).

Enhances cellular proliferation and differentiation and promotes apoptosis in vivo.

May play a role in tumorigenesis.

{ECO:0000250|UniProtKB:Q9HD15, ECO:0000269|PubMed:12350225}.