Rat Sulfotransferase Family 1E Member 1,SULT1E1 ELI

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone.

Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation.

Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency.

Does not sulfonate cortisol, testosterone and dopamine.

{ECO:0000250|UniProtKB:P49888}.