Rat Synaptotagmin 1,SYT1 ELI
3,140.00 ₪
Calcium sensor that participates in triggering neurotransmitter release at the synapse (PubMed:30107533).
May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse.
It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported.
It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
Plays a role in dendrite formation by melanocytes.
{ECO:0000250|UniProtKB:P21579, ECO:0000269|PubMed:30107533}.; (Microbial infection) Receptor for C.botulinum neurotoxin type B (BoNT/B, botB); interaction is improved in the presence of gangliosides (PubMed:8144634, PubMed:14504267, PubMed:17167418).
BoNT/B toxin binds to the membrane proximal vesicular domain of Syt1 (residues 32-51) (PubMed:14504267, PubMed:17167421).
{ECO:0000269|PubMed:14504267, ECO:0000269|PubMed:17167418, ECO:0000269|PubMed:17167421, ECO:0000269|PubMed:8144634}.; (Microbial infection) Receptor for C.botulinum neurotoxin type G (BoNT/G, botG); unlike the case with BoNT/B, interaction is not improved in the presence of gangliosides (PubMed:15123599, PubMed:20219474).
BoNT/G toxin binds to the vesicular domain of Syt1 (residues 32-53) (PubMed:15123599, PubMed:20219474).
{ECO:0000269|PubMed:15123599, ECO:0000269|PubMed:20219474}.
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