Rat Telomere Repeat Binding Factor 2, TRF2 ELI

May modulate transcriptional activation by target nuclear receptors.

Can act as transcriptional activator (in vitro).

Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1).

However, effects has been described variably.

Involved in the induction of starvation-induced autophagy.

Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3.

Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1.

May be involved in autophagosome biogenesis.

May play a role in neural progenitor cell survival during differentiation (By similarity).