Rat TNF Receptor Associated Factor 6,TRAF6 ELI

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2.

Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation.

Mediates activation of NF-kappa-B and JUN.

May be essential for the formation of functional osteoclasts.

Seems to also play a role in dendritic cells (DCs) maturation and/or activation.

Represses c-Myb-mediated transactivation, in B-lymphocytes.

Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor.

Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.

Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

{ECO:0000250|UniProtKB:Q9Y4K3}.