Rat Toll Interacting Protein, TOLLIP ELI

Component of the signaling pathway of IL-1 and Toll-like receptors.

Inhibits cell activation by microbial products.

Recruits IRAK1 to the IL-1 receptor complex.

Inhibits IRAK1 phosphorylation and kinase activity.

Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates.

The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).