Rat Transient receptor potential cation channel subfamily M member 7,Trpm7 ELI

Essential ion channel and serine/threonine-protein kinase.

Divalent cation channel permeable to calcium and magnesium.

Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death.

Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx.

The kinase activity is essential for the channel function.

May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell.

Phosphorylates annexin A1 (ANXA1) (By similarity).

{ECO:0000250}.