Rat Tristetraprolin,ZFP36 ELI

Zinc-finger RNA-binding protein that destabilizes numerous cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:27193233).

Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery.

Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation.

Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs.

Self regulates by destabilizing its own mRNA (By similarity).

Binds to 3'-UTR ARE of numerous mRNAs (PubMed:27193233).

Binds also to ARE of its own mRNA.

Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages.

Plays also a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response.

Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia.

Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs).

Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA.

Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA.

Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs.

Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs.

May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro.

Involved in the delivery of target ARE-mRNAs to processing bodies (PBs).

In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing.

Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages.

Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion.

Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis.

Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (By similarity).

{ECO:0000250|UniProtKB:P22893, ECO:0000250|UniProtKB:P26651, ECO:0000269|PubMed:27193233}.