Rat Ubiquitin-conjugating Enzyme E2 Variant 2, UBE2V2 ELI

Has no ubiquitin ligase activity on its own.

The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'.

This type of poly-ubiquitination does not lead to protein degradation by the proteasome.

Mediates transcriptional activation of target genes.

Plays a role in the control of progress through the cell cycle and differentiation.

Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.